CATH Classification

Domain Context

CATH Clusters

Superfamily MutM-like, N-terminal
Functional Family Formamidopyrimidine-DNA glycosylase

Enzyme Information
DNA-(apurinic or apyrimidinic site) lyase.
based on mapping to UniProt P42371
The C-O-P bond 3' to the apurinic or apyrimidinic site in DNA is broken by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate.
-!- 'Nicking' of the phosphodiester bond is due to a lyase-type reaction, not hydrolysis. -!- This group of enzymes was previously listed as endonucleases, under the number EC
DNA-formamidopyrimidine glycosylase.
based on mapping to UniProt P42371
Hydrolysis of DNA containing ring-opened 7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimidine.
-!- May play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents. -!- Also involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA.

UniProtKB Entries (1)

Lactococcus lactis subsp. cremoris
Formamidopyrimidine-DNA glycosylase

PDB Structure

External Links
Primary Citation
5-Hydroxy-5-Methylhydantoin DNA Lesion, a Molecular Trap for DNA Glycosylases
Le Bihan, Y.V., Izquierdo, M.A., Coste, F., Aller, P., Culard, F., Gehrke, T.H., Essalhi, K., Carrel, T., Castaing, B.
Nucleic Acids Res.