CATH Domain 2xwnA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.550	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
	3.90.550.10	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Domain Context

CATH Clusters

Superfamily	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family

Enzyme Information

2.7.7.60

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase.

based on mapping to UniProt P9WKG9

CTP + 2-C-methyl-D-erythritol 4-phosphate = diphosphate + 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol.

-!- ATP or UTP can replace CTP, but both are less effective. -!- GTP and TTP are not substrates. -!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

P9WKG9

ISPD_MYCTU

Mycobacterium tuberculosis H37Rv

2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

PDB Structure

PDB	2XWN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural and Functional Studies on Mycobacterial Ispd Enzymes Bjorkelid, C., Bergfors, T., Henriksson, L.M., Stern, A.L., Unge, T., Mowbray, S.L., Jones, T.A. Acta Crystallogr.,Sect.D