CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family

Enzyme Information

3.4.21.46
Complement factor D.
based on mapping to UniProt P00746
Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.
-!- A component of the alternative pathway of complement activation. -!- This reaction is analogous to the activation of complement component C2 by activated complement subcomponent C1s. -!- Belongs to peptidase family S1.

UniProtKB Entries (1)

P00746
CFAD_HUMAN
Homo sapiens
Complement factor D

PDB Structure

PDB 2XWA
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of C3B in Complex with Factors B and D Give Insight Into Complement Convertase Formation.
Forneris, F., Ricklin, D., Wu, J., Tzekou, A., Wallace, R.S., Lambris, J.D., Gros, P.
Science