CATH Classification

Domain Context

CATH Clusters

Superfamily JBP1, DNA-binding domain
Functional Family

Enzyme Information

1.14.11.6
Thymine dioxygenase.
based on mapping to UniProt Q9U6M1
Thymine + 2-oxoglutarate + O(2) = 5-hydroxymethyluracil + succinate + CO(2).
-!- Also acts on 5-hydroxymethyluracil to oxidize its -CH(2)-OH group first to -CHO and then to -COOH. -!- Formerly EC 1.14.11.5.

UniProtKB Entries (1)

Q9U6M1
JBP1_LEITA
Leishmania tarentolae
Thymine dioxygenase JBP1

PDB Structure

PDB 2XSE
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structural Basis for Recognition of Base J Containing DNA by a Novel DNA Binding Domain in Jbp1.
Heidebrecht, T., Christodoulou, E., Chalmers, M.J., Jan, S., Ter Riet, B., Grover, R.K., Joosten, R.P., Littler, D., Van Luenen, H., Griffin, P.R., Wentworth, P., Borst, P., Perrakis, A.
Nucleic Acids Res.