CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.58 | Methane Monooxygenase Hydroxylase; Chain G, domain 1 |
|
1.20.58.240 | STAT; domain 1 |
Domain Context
CATH Clusters
| Superfamily | STAT; domain 1 |
| Functional Family | O-GlcNAc selective N-Acetyl-beta-D-glucosaminidase (O-GlcNAcase) |
Enzyme Information
| 3.2.1.169 |
Protein O-GlcNAcase.
based on mapping to UniProt Q2CEE3
(1) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-serine + H(2)O = [protein]-L-serine + N-acetyl-D-glucosamine. (2) [Protein]-3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonine + H(2)O = [protein]-L-threonine + N-acetyl-D-glucosamine.
-!- Within higher eukaryotes post-translational modification of protein serines/threonines with N-acetylglucosamine (O-GlcNAc) is dynamic, inducible and abundant, regulating many cellular processes by interfering with protein phosphorylation. -!- EC 2.4.1.155 transfers GlcNAc onto substrate proteins and EC 3.2.1.169 cleaves GlcNAc from the modified proteins.
|
UniProtKB Entries (1)
| Q2CEE3 |
OGA_OCEGH
Oceanicola granulosus HTCC2516
Protein O-GlcNAcase
|
PDB Structure
| PDB | 2XSA |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Human Oga Binds Substrates in a Conserved Peptide Recognition Groove.
Biochem.J.
|