CATH Classification

Domain Context

CATH Clusters

Superfamily Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family Bifunctional IPC transferase and DIPP synthase

Enzyme Information

2.7.8.34
CDP-L-myo-inositol myo-inositolphosphotransferase.
based on mapping to UniProt O29976
CDP-1L-myo-inositol + 1L-myo-inositol 1-phosphate = CMP + bis(1L-myo- inositol) 3,1'-phosphate 1-phosphate.
-!- In many organisms this activity is catalyzed by a bifunctional enzyme. -!- The di-myo-inositol-1,3'-phosphate-1'-phosphate synthase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 uses only 1L-myo-inositol 1-phosphate as an alcohol acceptor, but CDP-glycerol, as well as CDP- 1L-myo-inositol and CDP-D-myo-inositol, are recognized as alcohol donors. -!- The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3- phosphate, a widespread organic solute in microorganisms adapted to hot environments.
2.7.7.74
1L-myo-inositol 1-phosphate cytidylyltransferase.
based on mapping to UniProt O29976
CTP + 1L-myo-inositol 1-phosphate = diphosphate + CDP-1L-myo-inositol.
-!- In many organisms this activity is catalyzed by a bifunctional enzyme. -!- The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 (CTP:inositol-1-phosphate cytidylyltransferase/CDP-inositol:inositol-1-phosphate transferase) is absolutely specific for CTP and 1L-myo-inositol 1-phosphate. -!- The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments. -!- In many organisms this activity is catalyzed by a bifunctional enzyme. -!- The cytidylyltransferase domain of the bifunctional EC 2.7.7.74/EC 2.7.8.34 is absolutely specific for CTP and 1L-myo- inositol 1-phosphate. -!- The enzyme is involved in biosynthesis of bis(1L-myo-inositol) 1,3'-phosphate, a widespread organic solute in microorganisms adapted to hot environments.

UniProtKB Entries (1)

O29976
DIPPS_ARCFU
Archaeoglobus fulgidus DSM 4304
Bifunctional IPC transferase and DIPP synthase

PDB Structure

PDB 2XMH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of Archaeoglobus fulgidus CTP:inositol-1-phosphate cytidylyltransferase, a key enzyme for di-myo-inositol-phosphate synthesis in (hyper)thermophiles.
Brito, J.A., Borges, N., Vonrhein, C., Santos, H., Archer, M.
J. Bacteriol.