CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.91.60
Functional Family RNA-directed RNA polymerase L

Enzyme Information

2.7.7.48
RNA-directed RNA polymerase.
based on mapping to UniProt A5HC98
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.1.-.-
Acting on ester bonds.
based on mapping to UniProt A5HC98

UniProtKB Entries (1)

A5HC98
L_BUNLC
La Crosse virus
RNA-directed RNA polymerase L

PDB Structure

PDB 2XI5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral CAP-Dependent Transcription.
Reguera, J., Weber, F., Cusack, S.
Plos Pathog.