CATH Classification

Domain Context

CATH Clusters

Superfamily DNA polymerase, Y-family, little finger domain
Functional Family DNA polymerase eta

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q04049
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q04049
POLH_YEAST
Saccharomyces cerevisiae S288C
DNA polymerase eta

PDB Structure

PDB 2XGP
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Mechanism of Replication Blocking and Bypass of Y-Family Polymerase Eta by Bulky Acetylaminofluorene DNA Adducts.
Schorr, S., Schneider, S., Lammens, K., Hopfner, K.P., Carell, T.
Proc.Natl.Acad.Sci.USA