CATH Classification

CATH Clusters

Superfamily 3.90.660.10
Functional Family Amine oxidase [flavin-containing] A

Enzyme Information

1.4.3.4
Monoamine oxidase.
based on mapping to UniProt P27338
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2).
-!- Catalyzes the oxidative deamination of neurotransmitters and biogenic amines. -!- Acts on primary amines, and also on some secondary and tertiary amines. -!- It differs from EC 1.4.3.21, as it can oxidize secondary and tertiary amines but not methylamine. -!- Inhibited by acetylenic compounds such as chlorgyline, 1-deprenyl and pargyline but, unlike EC 1.4.3.21 and EC 1.4.3.22, it is not inhibited by semicarbazide. -!- Formerly EC 1.4.3.9.

UniProtKB Entries (1)

P27338
AOFB_HUMAN
Homo sapiens
Amine oxidase [flavin-containing] B

PDB Structure

PDB 2XFQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Potentiation of ligand binding through cooperative effects in monoamine oxidase B.
Bonivento, D., Milczek, E.M., McDonald, G.R., Binda, C., Holt, A., Edmondson, D.E., Mattevi, A.
J. Biol. Chem.