CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.670
Functional Family DNA gyrase subunit B

Enzyme Information

5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt P66937
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.
5.6.2.3
DNA topoisomerase (ATP-hydrolyzing).
based on mapping to UniProt Q99XG5
ATP-dependent breakage, passage and rejoining of double-stranded DNA.
-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P66937
GYRB_STAAN
Staphylococcus aureus subsp. aureus N315
DNA gyrase subunit B

PDB Structure

PDB 2XCR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Type Iia Topoisomerase Inhibition by a New Class of Antibacterial Agents.
Bax, B.D., Chan, P.F., Eggleston, D.S., Fosberry, A., Gentry, D.R., Gorrec, F., Giordano, I., Hann, M.M., Hennessy, A., Hibbs, M., Huang, J., Jones, E., Jones, J., Brown, K.K., Lewis, C.J., May, E.W., Saunders, M.R., Singh, O., Spitzfaden, C., Shen, C., Shillings, A., Theobald, A.F., Wohlkonig, A., Pearson, N.D., Gwynn, M.N.
Nature