CATH Classification

Domain Context

CATH Clusters

Superfamily Glycogen Phosphorylase B;
Functional Family 3-deoxy-D-manno-octulosonic acid transferase

Enzyme Information

2.4.99.12
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase.
based on mapping to UniProt O66663
Lipid IV(A) + CMP-beta-Kdo = alpha-Kdo-(2->6)-lipid IV(A) + CMP.
-!- The bifunctional enzyme from Escherichia coli transfers two 3-deoxy- D-manno-octulosonate residues to lipid IV(A) (cf. EC 2.4.99.13). -!- The monofunctional enzymes from Aquifex aeolicus and Haemophilus influenzae catalyze the transfer of a single 3-deoxy-D-manno- octulosonate residue from CMP-3-deoxy-D-manno-octulosonate to lipid IV(A). -!- The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno- octulosonate residues and generate genus-specific epitopes.

UniProtKB Entries (1)

O66663
KDTA_AQUAE
Aquifex aeolicus VF5
3-deoxy-D-manno-octulosonic acid transferase

PDB Structure

PDB 2XCI
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Mechanistic Analysis of the Membrane-Embedded Glycosyltransferase Waaa Required for Lipopolysaccharide Synthesis.
Schmidt, H., Hansen, G., Singh, S., Hanuszkiewicz, A., Lindner, B., Fukase, K., Woodard, R.W., Holst, O., Hilgenfeld, R., Mamat, U., Mesters, J.R.
Proc.Natl.Acad.Sci.USA