CATH Classification

Domain Context

CATH Clusters

Superfamily Glucose-6-phosphate isomerase like protein; domain 1
Functional Family

Enzyme Information

5.3.1.28
D-sedoheptulose 7-phosphate isomerase.
based on mapping to UniProt Q93UJ2
D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate.
-!- In Gram-negative bacteria the enzyme is involved in biosynthesis of ADP-L-glycero-beta-D-manno-heptose, which is utilized for assembly of the lipopolysaccharide inner core. -!- In Gram-positive bacteria the enzyme is involved in biosynthesis of GDP-D-glycero-alpha-D-manno-heptose, which is required for assembly of S-layer glycoprotein.

UniProtKB Entries (1)

Q93UJ2
GMHA_BURPS
Burkholderia pseudomallei K96243
Phosphoheptose isomerase

PDB Structure

PDB 2XBL
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structure of Sedoheptulose-7-Phosphate Isomerase from Burkholderia Pseudomallei Reveals a Zinc Binding Site at the Heart of the Active Site.
Harmer, N.J.
J.Mol.Biol.