CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family Ephrin type-A receptor 5

Enzyme Information

2.7.10.1
Receptor protein-tyrosine kinase.
based on mapping to UniProt P54760
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
-!- The receptor protein-tyrosine kinases, which can be defined as having a transmembrane domain, are a large and diverse multigene family found only in metazoans. -!- In the human genome, 58 receptor-type protein-tyrosine kinases have been identified and these are distributed into 20 subfamilies. -!- Formerly EC 2.7.1.112.

UniProtKB Entries (1)

P54760
EPHB4_HUMAN
Homo sapiens
Ephrin type-B receptor 4

PDB Structure

PDB 2X9F
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibitors of the Tyrosine Kinase Ephb4. Part 3: Identification of Non-Benzodioxole-Based Kinase Inhibitors.
Bardelle, C., Barlaam, B., Brooks, N., Coleman, T., Cross, D., Ducray, R., Green, I., Brempt, C.L., Olivier, A., Read, J.
Bioorg.Med.Chem.Lett.