CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Receptor protein serine/threonine kinase

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt P36897
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P36897
TGFR1_HUMAN
Homo sapiens
TGF-beta receptor type-1

PDB Structure

PDB 2X7O
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design, Synthesis and Evaluation of Indolinones as Inhibitors of the Transforming Growth Factor Beta Receptor I (Tgfbri)
Roth, G.J., Heckel, A., Brandl, T., Grauert, M., Hoerer, S., Kley, J.T., Schnapp, G., Baum, P., Mennerich, D., Schnapp, A., Park, J.E.
J.Med.Chem.