CATH Classification

Domain Context

CATH Clusters

Superfamily Penicillin V Acylase; Chain A
Functional Family Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form

Enzyme Information

2.3.1.164
Isopenicillin-N N-acyltransferase.
based on mapping to UniProt P15802
Phenylacetyl-CoA + isopenicillin N + H(2)O = CoA + penicillin G + L-2- aminohexanedioate.
-!- Proceeds by a two stage mechanism via 6-aminopenicillanic acid. -!- Different from EC 3.5.1.11.

UniProtKB Entries (1)

P15802
AAAA_PENCH
Penicillium chrysogenum
Acyl-coenzyme A:6-aminopenicillanic-acid-acyltransferase 40 kDa form

PDB Structure

PDB 2X1E
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structures of an Isopenicillin N Converting Ntn-Hydrolase Reveal Different Catalytic Roles for the Active Site Residues of Precursor and Mature Enzyme.
Bokhove, M., Yoshida, H., Hensgens, C.M.H., Van Der Laan, J.M., Sutherland, J.D., Dijkstra, B.W.
Structure