CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.1370 | Ribosomal Protein S8; Chain: A, domain 1 |
|
3.30.1370.60 | Hypothetical oxidoreductase yiak; domain 2 |
Domain Context
CATH Clusters
| Superfamily | Hypothetical oxidoreductase yiak; domain 2 |
| Functional Family |
Enzyme Information
| 1.1.1.337 |
L-2-hydroxycarboxylate dehydrogenase (NAD(+)).
based on mapping to UniProt Q58820
A (2S)-2-hydroxycarboxylate + NAD(+) = a 2-oxocarboxylate + NADH.
-!- The enzyme from the archaeon Methanocaldococcus jannaschii acts on multiple L-2-hydroxycarboxylates including (2R)-3-sulfolactate, (S)- malate, (S)-lactate, and (S)-2-hydroxyglutarate. -!- Note that (2R)-3-sulfolactate has the same stereo configuration as (2S)-2-hydroxycarboxylates.
|
UniProtKB Entries (1)
| Q58820 |
COMC_METJA
Methanocaldococcus jannaschii DSM 2661
L-sulfolactate dehydrogenase
|
PDB Structure
| PDB | 2X06 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Methanoarchaeal Sulfolactate Dehydrogenase: Prototype of a New Family of Nadh-Dependent Enzymes.
Embo J.
|