CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1170 | Aldehyde Oxidoreductase; domain 3 |
|
3.90.1170.40 | Molybdopterin biosynthesis MoaE subunit |
Domain Context
CATH Clusters
| Superfamily | Molybdopterin biosynthesis MoaE subunit |
| Functional Family | Molybdopterin biosynthesis protein MoeE |
Enzyme Information
| 2.8.1.12 |
Molybdopterin synthase.
based on mapping to UniProt P9WJR3
Cyclic pyranopterin phosphate + 2 [molybdopterin-synthase sulfur-carrier protein]-Gly-NH-CH(2)-C(O)SH + H(2)O = molybdopterin + 2 [molybdopterin- synthase sulfur-carrier protein].
-!- Catalyzes the synthesis of molybdopterin from cyclic pyranopterin phosphate. -!- Two sulfur atoms are transferred to cyclic pyranopterin phosphate in order to form the characteristic ene-dithiol group found in the molybdenum cofactor. -!- Molybdopterin synthase consists of two large subunits forming a central dimer and two small subunits (molybdopterin-synthase sulfur- carrier proteins) that are thiocarboxylated at the C-terminus by EC 2.8.1.11, molybdopterin synthase sulfurtransferase. -!- The reaction occurs in prokaryotes and eukaryotes.
|
UniProtKB Entries (1)
| P9WJR3 |
MOAE1_MYCTU
Mycobacterium tuberculosis H37Rv
Molybdopterin synthase catalytic subunit 1
|
PDB Structure
| PDB | 2WP4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of Rv3119 from Mycobacterium Tuberculosis
To be Published
|