CATH Classification

Domain Context

CATH Clusters

Superfamily 3.10.450.40
Functional Family Primary amine oxidase

Enzyme Information

1.4.3.21
Primary-amine oxidase.
based on mapping to UniProt P46883
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2).
-!- A group of enzymes that oxidize primary monoamines but have little or no activity toward diamines, such as histamine, or toward secondary and tertiary amines. -!- They are copper quinoproteins (2,4,5-trihydroxyphenylalanine quinone) and, unlike EC 1.4.3.4, are sensitive to inhibition by carbonyl-group reagents, such as semicarbazide. -!- In some mammalian tissues the enzyme also functions as a vascular- adhesion protein (VAP-1). -!- Formerly EC 1.4.3.6.

UniProtKB Entries (1)

P46883
AMO_ECOLI
Escherichia coli K-12
Primary amine oxidase

PDB Structure

PDB 2WO0
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Exploring the Roles of the Metal Ions in Escherichia Coli Copper Amine Oxidase.
Smith, M.A., Pirrat, P., Pearson, A.R., Kurtis, C.R., Gaule, T.G., Knowles, P.F., Phillips, S.E., McPherson, M.J.
Biochemistry