CATH Domain 2wnfA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1480	sialyltransferase cstii, chain A
	3.90.1480.20	Glycosyl transferase family 29

Domain Context

CATH Clusters

Superfamily	Glycosyl transferase family 29
Functional Family	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

Enzyme Information

2.4.99.4

Beta-galactoside alpha-2,3-sialyltransferase.

based on mapping to UniProt Q02745

CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D- galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl- 1,3-N-acetyl-alpha-D-galactosaminyl-R.

-!- The acceptor is Gal-beta-1,3-GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid. -!- Lactose can also act as acceptor. -!- May be identical with EC 2.4.99.2.

UniProtKB Entries (1)

Q02745

SIA4A_PIG

Sus scrofa

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

PDB Structure

PDB	2WNF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Insight Into Mammalian Sialyltransferases. Rao, F.V., Rich, J.R., Rakic, B., Buddai, S., Schwartz, M.F., Johnson, K., Bowe, C., Wakarchuk, W.W., Defrees, S., Withers, S.G., Strynadka, N.C.J. Nat.Struct.Mol.Biol.