CATH Classification

Domain Context

CATH Clusters

Superfamily Glycosidases
Functional Family Chitinase A

Enzyme Information

3.2.1.14
Chitinase.
based on mapping to UniProt P07254
Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1->4)-beta- linkages in chitin and chitodextrins.
-!- The enzyme binds to chitin and randomly cleaves glycosidic linkages in chitin and chitodextrins in a non-processive mode, generating chitooligosaccharides and free ends on which exo-chitinases and exo- chitodextrinases can act. -!- Activity is greatly stimulated in the presence of EC 1.14.99.53, which attacks the crystalline structure of chitin and makes the polymer more accesible to the chitinase. -!- Cf. EC 3.2.1.202.

UniProtKB Entries (1)

P07254
CHIA_SERMA
Serratia marcescens
Chitinase A

PDB Structure

PDB 2WK2
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Chitinase Inhibition by Chitobiose and Chitotriose Thiazolines.
Macdonald, J.M., Tarling, C.A., Taylor, E.J., Dennis, R.J., Myers, D.S., Knapp, S., Davies, G.J., Withers, S.G.
Angew.Chem.Int.Ed.Engl.