CATH Classification

Domain Context

CATH Clusters

Superfamily Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain
Functional Family Succinate dehydrogenase flavoprotein subunit (SdhA)

Enzyme Information

1.3.5.1
Succinate dehydrogenase (quinone).
based on mapping to UniProt P0AC41
Succinate + a quinone = fumarate + a quinol.
-!- The enzyme is found in the inner mitochondrial membrane in eukaryotes and the plasma membrane of many aerobic or facultative bacteria. -!- It catalyzes succinate oxidation in the citric acid cycle and transfers the electrons to quinones in the membrane, thus constituting a part of the aerobic respiratory chain (known as complex II). -!- In vivo the enzyme uses the quinone found in the organism - eukaryotic enzymes utilize ubiquinone, bacterial enzymes utilize ubiquinone or menaquinone, and archaebacterial enzymes from the Sulfolobus genus use caldariellaquinone. -!- Cf. EC 1.3.5.4.

UniProtKB Entries (1)

P07014
SDHB_ECOLI
Escherichia coli K-12
Succinate dehydrogenase iron-sulfur subunit

PDB Structure

PDB 2WDQ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Escherichia coli succinate:quinone oxidoreductase with an occupied and empty quinone-binding site.
Ruprecht, J., Yankovskaya, V., Maklashina, E., Iwata, S., Cecchini, G.
J. Biol. Chem.