CATH Classification

Domain Context

CATH Clusters

Superfamily Homeodomain-like
Functional Family DNA-directed RNA polymerases I, II, and III subunit

Enzyme Information

2.7.7.6
DNA-directed RNA polymerase.
based on mapping to UniProt B8YB63
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

B8YB60
B8YB60_SACSH
Saccharolobus shibatae B12
DNA-directed RNA polymerase subunit H

PDB Structure

PDB 2WB1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Evolution of Complex RNA Polymerase: The Complete Archaeal RNA Polymerase Structure
Korkhin, Y., Unligil, U.M., Littlefield, O., Nelson, P.J., Stuart, D.I., Sigler, P.B., Bell, S.D., Abrescia, N.G.A.
Plos Biol.