CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Dihydrofolate reductase

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P13955
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P13955
DYRA_STAAU
Staphylococcus aureus
Dihydrofolate reductase type 1 from Tn4003

PDB Structure

PDB 2W9T
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Comparison of Chromosomal and Exogenous Dihydrofolate Reductase from Staphylococcus Aureus in Complex with the Potent Inhibitor Trimethoprim.
Heaslet, H., Harris, M., Fahnoe, K., Sarver, R., Putz, H., Chang, J., Subramanyam, C., Barreiro, G., Miller, J.R.
Proteins