CATH Classification

Domain Context

CATH Clusters

Superfamily DNA polymerase, Y-family, little finger domain
Functional Family

Enzyme Information

2.7.7.7
DNA-directed DNA polymerase.
based on mapping to UniProt Q97W02
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

Q97W02
DPO4_SACS2
Saccharolobus solfataricus P2
DNA polymerase IV

PDB Structure

PDB 2W9C
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure-Function Relationships in Miscoding by Sulfolobus Solfataricus DNA Polymerase Dpo4: Guanine N2,N2-Dimethyl Substitution Produces Inactive and Miscoding Polymerase Complexes.
Zhang, H., Eoff, R.L., Kosekov, I.D., Rizzo, C.J., Egli, M., Guengerich, F.P.
J.Biol.Chem.