CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Prostaglandin reductase 2

Enzyme Information

1.3.1.48
15-oxoprostaglandin 13-reductase.
based on mapping to UniProt Q8N8N7
11-alpha-hydroxy-9,15-dioxoprost-5-enoate + NAD(P)(+) = (5Z)-(13E)-11- alpha-hydroxy-9,15-dioxoprosta-5,13-dienoate + NAD(P)H.
-!- Reduces 15-oxoprostaglandins to 13,14-dihydro derivatives. -!- The enzyme from placenta is specific for NAD(+).

UniProtKB Entries (1)

Q8N8N7
PTGR2_HUMAN
Homo sapiens
Prostaglandin reductase 2

PDB Structure

PDB 2W98
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Zinc-Binding Alcohol Dehydrogenase 1
Shafqat, N., Yue, W.W., Niesen, F., Oppermann, U.
To be Published