CATH Classification

Domain Context

CATH Clusters

Superfamily Aldehyde Dehydrogenase; Chain A, domain 1
Functional Family Succinate-semialdehyde dehydrogenase, mitochondrial

Enzyme Information

1.2.1.24
Succinate-semialdehyde dehydrogenase (NAD(+)).
based on mapping to UniProt P51649
Succinate semialdehyde + NAD(+) + H(2)O = succinate + NADH.
-!- This enzyme participates in the degradation of glutamate and 4-aminobutyrate. -!- It is similar to EC 1.2.1.79 and EC 1.2.1.16 but is specific for NAD(+).

UniProtKB Entries (1)

P51649
SSDH_HUMAN
Homo sapiens
Succinate-semialdehyde dehydrogenase, mitochondrial

PDB Structure

PDB 2W8Q
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Redox-Switch Modulation of Human Ssadh by Dynamic Catalytic Loop.
Kim, Y.-G., Lee, S., Kwon, O.-S., Park, S.-Y., Lee, S.-J., Park, B.-J., Kim, K.-J.
Embo J.