CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Glyceraldehyde-3-phosphate dehydrogenase

Enzyme Information

1.2.1.12
Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating).
based on mapping to UniProt P0A9B2
D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = 3-phospho-D-glyceroyl phosphate + NADH.
-!- Also acts very slowly on D-glyceraldehyde and some other aldehydes. -!- Thiols can replace phosphate.

UniProtKB Entries (2)

Q9ESV6
G3PT_RAT
Rattus norvegicus
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific
P0A9B2
G3P1_ECOLI
Escherichia coli K-12
Glyceraldehyde-3-phosphate dehydrogenase A

PDB Structure

PDB 2VYN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure of Insoluble Rat Sperm Glyceraldehyde-3-Phosphate Dehydrogenase (Gapdh) Via Heterotetramer Formation with Escherichia Coli Gapdh Reveals Target for Contraceptive Design.
Frayne, J., Taylor, A., Cameron, G., Hadfield, A.T.
J.Biol.Chem.