CATH Classification

Domain Context

CATH Clusters

Superfamily Histone deacetylase domain
Functional Family

Enzyme Information

3.5.1.98
Histone deacetylase.
based on mapping to UniProt P56524
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.
-!- A class of enzymes that remove acetyl groups from N(6)-acetyl-lysine residues on a histone. -!- The reaction of this enzyme is opposite to that of EC 2.3.1.48. -!- Histone deacetylases (HDACs) can be organized into three classes depending on sequence similarity and domain organization. -!- Histone acetylation plays an important role in regulation of gene expression. -!- In eukaryotes, HDACs play a key role in the regulation of transcription and cell proliferation. -!- May be identical to EC 3.5.1.17.

UniProtKB Entries (1)

P56524
HDAC4_HUMAN
Homo sapiens
Histone deacetylase 4

PDB Structure

PDB 2VQV
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural and Functional Analysis of the Human Hdac4 Catalytic Domain Reveals a Regulatory Structural Zinc-Binding Domain.
Bottomley, M.J., Lo Surdo, P., Di Giovine, P., Cirillo, A., Scarpelli, R., Ferrigno, F., Jones, P., Neddermann, P., De Francesco, R., Steinkuhler, C., Gallinari, P., Carfi, A.
J.Biol.Chem.