CATH Classification

Domain Context

CATH Clusters

Superfamily Aspartate Aminotransferase, domain 1
Functional Family Tyrosine phenol-lyase

Enzyme Information

4.1.99.2
Tyrosine phenol-lyase.
based on mapping to UniProt P31013
L-tyrosine + H(2)O = phenol + pyruvate + NH(3).
-!- The enzyme cleaves a carbon-carbon bond, releasing phenol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. -!- The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10. -!- The enzyme also slowly catalyzes similar reactions with D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.

UniProtKB Entries (1)

P31013
TPL_CITFR
Citrobacter freundii
Tyrosine phenol-lyase

PDB Structure

PDB 2VLH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Insights Into the Catalytic Mechanism of Tyrosine Phenol-Lyase from X-Ray Structures of Quinonoid Intermediates.
Milic, D., Demidkina, T.V., Faleev, N.G., Matkovic-Calogovic, D., Antson, A.A.
J.Biol.Chem.