CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.970
Functional Family Pyruvate decarboxylase isozyme

Enzyme Information

4.1.1.74
Indolepyruvate decarboxylase.
based on mapping to UniProt P06169
3-(indol-3-yl)pyruvate = 2-(indol-3-yl)acetaldehyde + CO(2).
-!- More specific than EC 4.1.1.1.
4.1.1.-
Carboxy-lyases.
based on mapping to UniProt P06169
4.1.1.72
Branched-chain-2-oxoacid decarboxylase.
based on mapping to UniProt P06169
(3S)-3-methyl-2-oxopentanoate = 2-methylbutanal + CO(2).
-!- Acts on a number of 2-oxo acids, with a high affinity toward branched-chain substrates. -!- The aldehyde formed may be enzyme-bound, and may be an intermediate in the bacterial system for biosynthesis of branched-chain fatty acids.
4.1.1.43
Phenylpyruvate decarboxylase.
based on mapping to UniProt P06169
Phenylpyruvate = phenylacetaldehyde + CO(2).
-!- Also acts on (indol-3-yl)pyruvate.

UniProtKB Entries (1)

P06169
PDC1_YEAST
Saccharomyces cerevisiae S288C
Pyruvate decarboxylase isozyme 1

PDB Structure

PDB 2VK8
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Covalently Bound Substrate at the Regulatory Site of Yeast Pyruvate Decarboxylases Triggers Allosteric Enzyme Activation.
Kutter, S., Weiss, M.S., Wille, G., Golbik, R., Spinka, M., Konig, S.
J.Biol.Chem.