CATH Classification

Domain Context

CATH Clusters

Superfamily Trypsin-like serine proteases
Functional Family Urokinase-type plasminogen activator

Enzyme Information

3.4.21.73
U-plasminogen activator.
based on mapping to UniProt P00749
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- Formed from the inactive precursor by action of plasmin or plasma kallikrein. -!- Differs in structure from EC 3.4.21.68, and does not bind to fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.

UniProtKB Entries (1)

P00749
UROK_HUMAN
Homo sapiens
Urokinase-type plasminogen activator

PDB Structure

PDB 2VIO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Fragment-Based Discovery of Mexiletine Derivatives as Orally Bioavailable Inhibitors of Urokinase-Type Plasminogen Activator
Frederickson, M., Callaghan, O., Chessari, G., Congreve, M., Cowan, S.R., Matthews, J.E., Mcmenamin, R., Smith, D., Vinkovic, M., Wallis, N.G.
J.Med.Chem.