CATH Classification

Domain Context

CATH Clusters

Superfamily Acyl-CoA dehydrogenase/oxidase, N-terminal domain
Functional Family Acyl-CoA dehydrogenase FadE19

Enzyme Information

1.3.8.1
Short-chain acyl-CoA dehydrogenase.
based on mapping to UniProt P16219
A short-chain acyl-CoA + electron-transfer flavoprotein = a short-chain trans-2,3-dehydroacyl-CoA + reduced electron-transfer flavoprotein.
-!- One of several enzymes that catalyze the first step in fatty acids beta-oxidation. -!- The enzyme catalyzes the oxidation of saturated short-chain acyl-CoA thioesters to give a trans 2,3-unsaturated product by removal of the two pro-R hydrogen atoms. -!- The enzyme from beef liver accepts substrates with acyl chain lengths of 3 to 8 carbon atoms. -!- The highest activity was reported with either butanoyl-CoA or pentanoyl-CoA. -!- The enzyme from rat has only 10% activity with hexanoyl-CoA (compared to butanoyl-CoA) and no activity with octanoyl-CoA. -!- Cf. EC 1.3.8.7, EC 1.3.8.8 and EC 1.3.8.9. -!- Formerly EC 1.3.2.1 and EC 1.3.99.2.

UniProtKB Entries (1)

P16219
ACADS_HUMAN
Homo sapiens
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

PDB Structure

PDB 2VIG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal Structure of Human Short-Chain Acyl Coa Dehydrogenase
Pike, A.C.W., Pantic, N., Parizotto, E., Gileadi, O., Ugochukwu, E., von Delft, F., Weigelt, J., Arrowsmith, C.H., Edwards, A., Oppermann, U.
To be Published