CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.960 | Lumazine/riboflavin synthase |
Domain Context
CATH Clusters
| Superfamily | Lumazine/riboflavin synthase |
| Functional Family | 6,7-dimethyl-8-ribityllumazine synthase |
Enzyme Information
| 2.5.1.78 |
6,7-dimethyl-8-ribityllumazine synthase.
based on mapping to UniProt P9WHE9
1-deoxy-L-glycero-tetrulose 4-phosphate + 5-amino-6- (D-ribitylamino)uracil = 6,7-dimethyl-8-(D-ribityl)lumazine + 2 H(2)O + phosphate.
-!- Involved in riboflavin biosynthesis.
|
UniProtKB Entries (1)
| P9WHE9 |
RISB_MYCTU
Mycobacterium tuberculosis H37Rv
6,7-dimethyl-8-ribityllumazine synthase
|
PDB Structure
| PDB | 2VI5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A New Series of N-[2,4-Dioxo-6-D-Ribitylamino-1,2, 3,4-Tetrahydropyrimidin-5-Yl]Oxalamic Acid Derivatives as Inhibitors of Lumazine Syntase and Riboflavin Synthase: Design, Synthesis, Biochemical Evaluation, Crystallography and Mechanistic Implications.
J.Org.Chem.
|
