CATH Classification

Domain Context

CATH Clusters

Superfamily Cysteine proteinases
Functional Family Putative ubiquitin carboxyl-terminal hydrolase CYLD

Enzyme Information

3.4.19.12
Ubiquitinyl hydrolase 1.
based on mapping to UniProt Q9NQC7
Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).
-!- Links to polypeptides smaller than 60 residues are hydrolyzed more readily than those to larger polypeptides. -!- Isoforms exist with quantitatively different specificities among the best known being UCH-L1 and UCH-L3, major proteins of the brain of mammals. -!- Inhibited by ubiquitin aldehyde (in which Gly76 is replaced by aminoacetaldehyde). -!- Belongs to peptidase family C12.

UniProtKB Entries (1)

Q9NQC7
CYLD_HUMAN
Homo sapiens
Ubiquitin carboxyl-terminal hydrolase CYLD

PDB Structure

PDB 2VHF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structure of the Cyld Usp Domain Explains its Specificity for Lys63-Linked Polyubiquitin and Reveals a B-Box Module
Komander, D., Lord, C.J., Scheel, H., Swift, S., Hofmann, K., Ashworth, A., Barford, D.
Mol.Cell.Biol.