CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphoenolpyruvate-binding domains
Functional Family Pyruvate kinase

Enzyme Information

2.7.1.40
Pyruvate kinase.
based on mapping to UniProt P30613
ATP + pyruvate = ADP + phosphoenolpyruvate.
-!- UTP, GTP, CTP, ITP and dATP can also act as donors. -!- Also phosphorylates hydroxylamine and fluoride in the presence of CO(2).

UniProtKB Entries (1)

P30613
KPYR_HUMAN
Homo sapiens
Pyruvate kinase PKLR

PDB Structure

PDB 2VGF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structure and Function of Human Erythrocyte Pyruvate Kinase. Molecular Basis of Nonspherocytic Hemolytic Anemia.
Valentini, G., Chiarelli, L.R., Fortin, R., Dolzan, M., Galizzi, A., Abraham, D.J., Wang, C., Bianchi, P., Zanella, A., Mattevi, A.
J.Biol.Chem.