CATH Classification

Domain Context

CATH Clusters

Superfamily Glucose-6-phosphate isomerase like protein; domain 1
Functional Family Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Enzyme Information

2.6.1.16
Glutamine--fructose-6-phosphate transaminase (isomerizing).
based on mapping to UniProt P17169
L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.
-!- Although the overall reaction is that of a transferase, the mechanism involves the formation of ketimine between fructose 6-phosphate and a 6-amino group from a lysine residue at the active site, which is subsequently displaced by ammonia (transamidination). -!- Formerly EC 5.3.1.19.

UniProtKB Entries (1)

P17169
GLMS_ECOLI
Escherichia coli K-12
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

PDB Structure

PDB 2VF5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Ordering of C-Terminal Loop and Glutaminase Domains of Glucosamine-6-Phosphate Synthase Promotes Sugar Ring Opening and Formation of the Ammonia Channel.
Mouilleron, S., Badet-Denisot, M.-A., Golinelli-Pimpaneau, B.
J.Mol.Biol.