1 keywords

CATH Domain 2vd6A02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.20 Up-down Bundle
Topology 1.20.200 Fumarase C; Chain A, domain 2
Homologous Superfamily 1.20.200.10 Fumarase/aspartase (Central domain)

Domain Context

CATH Clusters

Superfamily Fumarase/aspartase (Central domain)
Functional Family

Enzyme Information

4.3.2.2
Adenylosuccinate lyase.
based on mapping to UniProt P30566
(1) N(6)-(1,2-dicarboxyethyl)AMP = fumarate + AMP. (2) (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate = fumarate + 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide.
-!- Also acts on 1-(5-phosphoribosyl)-4-(N-succinocarboxamide)-5- aminoimidazole.

UniProtKB Entries (1)

P30566
PUR8_HUMAN
Homo sapiens
Adenylosuccinate lyase

PDB Structure

PDB 2VD6
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Human Adenylosuccinate Lyase in Complex with its Substrate N6-(1,2-Dicarboxyethyl)-AMP, and its Products AMP and Fumarate.
Stenmark, P., Moche, M., Arrowsmith, C., Berglund, H., Busam, R., Collins, R., Dahlgren, L.G., Edwards, A., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hallberg, B.M., Holmberg-Schiavone, L., Johansson, I., Kallas, A., Karlberg, T., Kotenyova, T., Lehtio, L., Nilsson, M., Nyman, T., Ogg, D., Persson, C., Sagemark, J., Sundstrom, M., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Weigelt, J., Welin, M., Nordlund, P.
To be Published