CATH Classification

Domain Context

CATH Clusters

Superfamily 1.20.1050.10
Functional Family Hematopoietic prostaglandin D synthase

Enzyme Information

2.5.1.18
Glutathione transferase.
based on mapping to UniProt O60760
RX + glutathione = HX + R-S-glutathione.
-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.
5.3.99.2
Prostaglandin-D synthase.
based on mapping to UniProt O60760
(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.
-!- Brings about the opening of the epidioxy bridge.

UniProtKB Entries (1)

O60760
HPGDS_HUMAN
Homo sapiens
Hematopoietic prostaglandin D synthase

PDB Structure

PDB 2VCZ
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design.
Hohwy, M., Spadola, L., Lundquist, B., Hawtin, P., Dahmen, J., Groth-Clausen, I., Nilsson, E., Persdotter, S., Von Wachenfeldt, K., Folmer, R.H.A., Edman, K.
J.Med.Chem.