CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.60 | Sandwich |
|
2.60.120 | Jelly Rolls |
|
2.60.120.330 | B-lactam Antibiotic, Isopenicillin N Synthase; Chain |
Domain Context
CATH Clusters
| Superfamily | B-lactam Antibiotic, Isopenicillin N Synthase; Chain |
| Functional Family | Isopenicillin N synthase |
Enzyme Information
| 1.21.3.1 |
Isopenicillin-N synthase.
based on mapping to UniProt P05326
N-((5S)-5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + O(2) = isopenicillin N + 2 H(2)O.
-!- Forms part of the penicillin biosynthesis pathway.
|
UniProtKB Entries (1)
| P05326 |
IPNS_EMENI
Aspergillus nidulans FGSC A4
Isopenicillin N synthase
|
PDB Structure
| PDB | 2VBB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Isopenicillin N Synthase Mediates Thiolate Oxidation to Sulfenate in a Depsipeptide Substrate Analogue: Implications for Oxygen Binding and a Link to Nitrile Hydratase?
J.Am.Chem.Soc.
|