CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.1190.20
Functional Family 2-dehydro-3-deoxygluconokinase

Enzyme Information

2.7.1.178
2-dehydro-3-deoxyglucono/galactono-kinase.
based on mapping to UniProt Q97U29
(1) ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + 2-dehydro-3-deoxy-6- phospho-D-gluconate. (2) ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-6- phospho-D-galactonate.
-!- The enzyme from the archaeon Sulfolobus solfataricus is involved in glucose and galactose catabolism via the branched variant of the Entner-Doudoroff pathway. -!- It phosphorylates 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3- deoxy-D-galactonate with similar catalytic efficiency. -!- Cf. EC 2.7.1.45 and EC 2.7.1.58.

UniProtKB Entries (1)

Q97U29
KDGK_SACS2
Saccharolobus solfataricus P2
2-dehydro-3-deoxygluconokinase/2-dehydro-3-deoxygalactonokinase

PDB Structure

PDB 2VAR
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The Structure of Sulfolobus Solfataricus 2-Keto-3-Deoxygluconate Kinase.
Potter, J.A., Kerou, M., Lamble, H.J., Bull, S.D., Hough, D.W., Danson, M.J., Taylor, G.L.
Acta Crystallogr.,Sect.D