CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.50.880
Functional Family CTP synthase

Enzyme Information

6.3.4.2
CTP synthase (glutamine hydrolyzing).
based on mapping to UniProt Q9NRF8
ATP + UTP + L-glutamine = ADP + phosphate + CTP + L-glutamate.
-!- The enzyme contains three functionally distinct sites: an allosteric GTP-binding site, a glutaminase site where glutamine hydrolysis occurs (cf. EC 3.5.1.2), and the active site where CTP synthesis takes place. -!- The reaction proceeds via phosphorylation of UTP by ATP to give an activated intermediate 4-phosphoryl UTP and ADP. -!- Ammonia then reacts with this intermediate generating CTP and a phosphate. -!- The enzyme can also use ammonia from the surrounding solution.

UniProtKB Entries (1)

Q9NRF8
PYRG2_HUMAN
Homo sapiens
CTP synthase 2

PDB Structure

PDB 2V4U
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Human Ctp Synthetase 2 - Glutaminase Domain in Complex with 5-Oxo-L-Norleucine
Welin, M., Moche, M., Andersson, J., Arrowsmith, C.H., Berglund, H., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Lehtio, L., Nilsson, M.E., Nyman, T., Olesen, K., Persson, C., Sagemark, J., Schueler, H., Thorsell, A.G., Tresaugues, L., Van Den Berg, S., Wisniewska, M., Weigelt, J., Wikstrom, M., Nordlund, P.
To be Published