CATH Classification

Domain Context

CATH Clusters

Superfamily 3.40.5.120
Functional Family chromodomain-helicase-DNA-binding protein 9 isoform X1

Enzyme Information

3.6.4.12
DNA helicase.
based on mapping to UniProt Q9P2D1
ATP + H(2)O = ADP + phosphate.
-!- DNA helicases utilize the energy from ATP hydrolysis to unwind double-stranded DNA. -!- Some of them unwind duplex DNA with a 3' to 5' polarity (1,3,5,8), other show 5' to 3' polarity (10,11,12,13) or unwind DNA in both directions (14,15). -!- Some helicases unwind DNA as well as RNA (4,9). -!- May be identical with EC 3.6.4.13 (RNA helicase).

UniProtKB Entries (1)

Q9P2D1
CHD7_HUMAN
Homo sapiens
Chromodomain-helicase-DNA-binding protein 7

PDB Structure

PDB 2V0E
External Links
Method SOLUTION NMR
Organism
Primary Citation
Solution Structure of the Brk Domains from Chd7
Allen, M.D., Religa, T.L., Freund, S.M.V., Bycroft, M.
J.Mol.Biol.