CATH Classification

Domain Context

CATH Clusters

Superfamily Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Functional Family Metallo-beta-lactamase type 2

Enzyme Information

3.5.2.6
Beta-lactamase.
based on mapping to UniProt P04190
A beta-lactam + H(2)O = a substituted beta-amino acid.
-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

P04190
BLA2_BACCE
Bacillus cereus
Metallo-beta-lactamase type 2

PDB Structure

PDB 2UYX
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Asp-120 locates Zn2 for optimal metallo-beta-lactamase activity.
Llarrull, L.I., Fabiane, S.M., Kowalski, J.M., Bennett, B., Sutton, B.J., Vila, A.J.
J. Biol. Chem.