CATH Classification

Domain Context

CATH Clusters

Superfamily Membrane associated eicosanoid/glutathione metabolism-like domain
Functional Family Microsomal glutathione S-transferase 2

Enzyme Information

4.4.1.20
Leukotriene-C(4) synthase.
based on mapping to UniProt Q16873
Leukotriene C(4) = leukotriene A(4) + glutathione.
-!- The reaction proceeds in the direction of addition. -!- Not identical with EC 2.5.1.18. -!- Formerly EC 2.5.1.37.

UniProtKB Entries (1)

Q16873
LTC4S_HUMAN
Homo sapiens
Leukotriene C4 synthase

PDB Structure

PDB 2UUH
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural Basis for Synthesis of Inflammatory Mediators by Human Leukotriene C4 Synthase.
Martinez Molina, D., Wetterholm, A., Kohl, A., Mccarthy, A.A., Niegowski, D., Ohlson, E., Hammarberg, T., Eshaghi, S., Haeggstrom, J.Z., Nordlund, P.
Nature