CATH Classification

Domain Context

CATH Clusters

Superfamily 2.120.10.10
Functional Family Sialidase

Enzyme Information

3.2.1.18
Exo-alpha-sialidase.
based on mapping to UniProt P29768
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
-!- The enzyme does not act on 4-O-acetylated sialic acids. -!- An endo-alpha-sialidase activity is listed as EC 3.2.1.129. -!- See also EC 4.2.2.15.

UniProtKB Entries (1)

P29768
NANH_SALTY
Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
Sialidase

PDB Structure

PDB 2SIM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
The structures of Salmonella typhimurium LT2 neuraminidase and its complexes with three inhibitors at high resolution.
Crennell, S.J., Garman, E.F., Philippon, C., Vasella, A., Laver, W.G., Vimr, E.R., Taylor, G.L.
J.Mol.Biol.