CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein phosphatase non-receptor type

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q06124
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

Q06124
PTN11_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 11

PDB Structure

PDB 2SHP
External Links
Method X-RAY DIFFRACTION
Organism Escherichia
Primary Citation
Crystal structure of the tyrosine phosphatase SHP-2.
Hof, P., Pluskey, S., Dhe-Paganon, S., Eck, M.J., Shoelson, S.E.
Cell(Cambridge,Mass.)