CATH Classification

Domain Context

CATH Clusters

Superfamily Peptidase S8/S53 domain
Functional Family

Enzyme Information

3.4.21.62
Subtilisin.
based on mapping to UniProt P00780
Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.
-!- Subtilisin is a serine endopeptidase that evolved independently of chymotrypsin. -!- It contains no cysteine residues (although these are found in homologous enzymes). -!- Species variants include subtilisin BPN' (also subtilisin B, subtilopeptidase C, nagarse, nagarse proteinase, subtilisin Novo, bacterial proteinase Novo) and subtilisin Carlsberg (subtilisin A, subtilopeptidase A, alcalase Novo). -!- Similar enzymes are produced by various Bacillus subtilis strains and other Bacillus species. -!- Belongs to peptidase family S8. -!- Formerly EC 3.4.4.16 and EC 3.4.21.14.

UniProtKB Entries (2)

P00780
SUBT_BACLI
Bacillus licheniformis
Subtilisin Carlsberg
P01051
ICIC_HIRME
Hirudo medicinalis
Eglin C

PDB Structure

PDB 2SEC
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural comparison of two serine proteinase-protein inhibitor complexes: eglin-c-subtilisin Carlsberg and CI-2-subtilisin Novo.
McPhalen, C.A., James, M.N.
Biochemistry