CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.58 | Methane Monooxygenase Hydroxylase; Chain G, domain 1 |
|
1.20.58.80 | Phosphotransferase system, lactose/cellobiose-type IIA subunit |
Domain Context
CATH Clusters
| Superfamily | Phosphotransferase system, lactose/cellobiose-type IIA subunit |
| Functional Family | Katanin p60 ATPase-containing subunit A1 |
Enzyme Information
| 5.6.1.1 |
Microtubule-severing ATPase.
based on mapping to UniProt Q9WV86
n ATP + n H(2)O + a microtubule = n ADP + n phosphate + (n+1) alpha/beta tubulin heterodimers.
-!- A member of the AAA-ATPase family, active in splitting microtubules into tubulin dimers in the centrosome. -!- Formerly EC 3.6.4.3.
|
UniProtKB Entries (1)
| Q9WV86 |
KTNA1_MOUSE
Mus musculus
Katanin p60 ATPase-containing subunit A1
|
PDB Structure
| PDB | 2RPA |
| External Links | |
| Method | SOLUTION NMR |
| Organism | |
| Primary Citation |
A common substrate recognition mode conserved between katanin P60 and VPS4 governs microtubule severing and membrane skeleton reorganization
J.Biol.Chem.
|