CATH Classification

Domain Context

CATH Clusters

Superfamily SH2 domain
Functional Family Tyrosine-protein phosphatase non-receptor type

Enzyme Information

3.1.3.48
Protein-tyrosine-phosphatase.
based on mapping to UniProt P29350
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

UniProtKB Entries (1)

P26715
NKG2A_HUMAN
Homo sapiens
NKG2-A/NKG2-B type II integral membrane protein

PDB Structure

PDB 2RMX
External Links
Method SOLUTION NMR
Organism
Primary Citation
Structural basis for the recognition of the two NKG2A immunoreceptor tyrosine-based inhibitory motifs (ITIMs) by the C-terminal SH2 domain of protein tyrosine phosphatase SHP-1
Koshiba, S., Kasai, T., Sato, M., Tomizawa, T., Motoda, Y., Tochio, N., Kobayashi, N., Harada, T., Inoue, M., Tanaka, A., Kigawa, T., Yokoyama, S.
To be Published