CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Serine/threonine-protein kinase PLK

Enzyme Information

2.7.11.21
Polo kinase.
based on mapping to UniProt P53350
ATP + a protein = ADP + a phosphoprotein.
-!- The enzyme associates with the spindle pole during mitosis and is thought to play an important role in the dynamic function of the mitotic spindle during chromosome segregation. -!- The human form of the enzyme, Plk1, does not phosphorylate histone H1, enolase and phosvitin but it can phosphorylate myelin basic protein and microtubule-associated protein MAP-2, although to a lesser extent than casein. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P53350
PLK1_HUMAN
Homo sapiens
Serine/threonine-protein kinase PLK1

PDB Structure

PDB 2RKU
External Links
Method X-RAY DIFFRACTION
Organism Spodoptera
Primary Citation
Selectivity-determining residues in Plk1.
Kothe, M., Kohls, D., Low, S., Coli, R., Rennie, G.R., Feru, F., Kuhn, C., Ding, Y.-H.
Chem.Biol.Drug Des.